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It is distressing to see signs that our success in encouraging tobacco users to quita challenging behavior change given the highly addictive nature of nicotinehas been slowed over the past year-and-a-half

Similar cautionary perspectives have been documented regarding the safety, efficacy, and harms of e-cigarettes, emphasizing concerns around their role as potential gateway products to tobacco use, and highlighting significant apprehension about dual use patterns [5, 18]

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C max , terminal half-life (t 1/2 ), AUC from time 0 extrapolated to infinity [AUC (0)], and AUC from time 0 to the last quantifiable concentration [AUC (0, t last )] were the primary PK endpoints